Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00558) | ||||||
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| BTS Name |
G-protein coupled receptor homolog US28
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| Synonyms |
HHRF3
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| BTS Type |
Protein
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| Family |
G-protein coupled receptor 1 family
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| Gene Name |
US28
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| Organism |
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5)
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| Function |
Receptor for a C-C type chemokine. Binds to MIP-1 alpha, RANTES, and MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. May regulate viral latency or reactivation; potential pathway for virally transformed cell proliferation.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Sequence |
MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITW
RRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLC FITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYL EVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIF WLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQ ELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP |
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| Sequence Length |
354
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Nanobody anti-US28Nb7 B1 | Research | Binder | N.A. | Research tool | [1] | |