General Information of Binding Target of SBP (BTS) (ID: ST00418)
BTS Name
Gitoxin
Synonyms
Gitoxin
BTS Type
Small Molecule
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Fab anti-Digitoxin/Gitoxin 26-10 Research Binder N.A. Tools for modifying specificity of antidigoxin antibodies
SBP Info
[1], [2]
Fab anti-Digitoxin/Gitoxin IGS10 Research Binder N.A. Tools for modifying specificity of antidigoxin antibodies
SBP Info
[3], [4]
Fab anti-Gitoxin G11 Research Binder Kd: 0.2 nM Research tool
SBP Info
[2]
Fab anti-Gitoxin G12 Research Binder Kd: 0.2 nM Research tool
SBP Info
[2]
Fab anti-Gitoxin G6 Research Binder Kd: 1.5 nM Research tool
SBP Info
[2]
References
1 Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding. J Biol Chem. 2002 May 10;277(19):16365-70.
2 A single H:CDR3 residue in the anti-digoxin antibody 26-10 modulates specificity for C16-substituted digoxin analogs. Protein Eng. 2001 Apr;14(4):287-96.
3 Modifying specificity of antidigoxin antibodies using insertional mutagenesis. Protein Sci. 2002 Dec;11(12):2899-908.
4 Phage display-selected sequences of the heavy-chain CDR3 loop of the anti-digoxin antibody 26-10 define a high affinity binding site for position 16-substituted analogs of digoxin. J Biol Chem. 2001 Mar 16;276(11):8149-58.