Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00417)
BTS Name	Digitoxin
Synonyms	Digitoxin
BTS Type	Small Molecule

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Fab anti-Digitoxin 5GS4	Research	Binder	N.A.	Tools for modifying specificity of antidigoxin antibodies	SBP Info	[1], [2]
Fab anti-Digitoxin IDW1	Research	Binder	N.A.	Tools for modifying specificity of antidigoxin antibodies	SBP Info	[1], [2]
Fab anti-Digitoxin IDW3	Research	Binder	N.A.	Tools for modifying specificity of antidigoxin antibodies	SBP Info	[1], [2]
Fab anti-Digitoxin/Gitoxin 26-10	Research	Binder	N.A.	Tools for modifying specificity of antidigoxin antibodies	SBP Info	[3], [4]
Fab anti-Digitoxin/Gitoxin IGS10	Research	Binder	N.A.	Tools for modifying specificity of antidigoxin antibodies	SBP Info	[1], [2]

References

1	Modifying specificity of antidigoxin antibodies using insertional mutagenesis. Protein Sci. 2002 Dec;11(12):2899-908.
2	Phage display-selected sequences of the heavy-chain CDR3 loop of the anti-digoxin antibody 26-10 define a high affinity binding site for position 16-substituted analogs of digoxin. J Biol Chem. 2001 Mar 16;276(11):8149-58.
3	Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding. J Biol Chem. 2002 May 10;277(19):16365-70.
4	A single H:CDR3 residue in the anti-digoxin antibody 26-10 modulates specificity for C16-substituted digoxin analogs. Protein Eng. 2001 Apr;14(4):287-96.