General Information of Binding Target of SBP (BTS) (ID: ST00404)
BTS Name
Fc-gammaRIIA
Synonyms
Fc-gammaRIIA
BTS Type
Protein
Organism
Homo sapiens (Human)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DARPin anti-Fc-gamma-RIIA/RIIB clone D11_D11 Research Binder Kd: 0.056 nM Allergies [ICD-11: 4A84.Z]
SBP Info
[1], [2]
DARPin anti-Fc-gamma-RIIA/RIIB clone D11_E53 Research Binder Kd: 26 nM Allergies [ICD-11: 4A84.Z]
SBP Info
[1], [2]
References
1 Current Strategies to Inhibit High Affinity FcRI-Mediated Signaling for the Treatment of Allergic Disease. Front Immunol. 2019 Feb 7;10:175.
2 A novel bispecific DARPin targeting FcRIIB and FcRI-bound IgE inhibits allergic responses. Allergy. 2017 Aug;72(8):1174-1183.