Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00336) | ||||||
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| BTS Name |
Complement factor D
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| Synonyms |
EC 3.4.21.46; Adipsin; C3 convertase activator; Properdin factor D
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| BTS Type |
Protein
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| Family |
Peptidase S1 family
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| Gene Name |
CFD
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| Organism |
Homo sapiens (Human)
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| Function |
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQW
VLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQL SEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCN RRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTR VASYAAWIDSVLA |
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| Sequence Length |
253
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Fab Lampalizumab | Phase III | Inhibitor | N.A. | Geographic Atrophy; Dry age related macular degeneration [ICD-11: 9B75.02] | [1] | |