Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00335)
BTS Name
Platelet glycoprotein VI
Synonyms
GPVI; Glycoprotein 6
BTS Type
Protein
Gene Name
GP6
Organism
Homo sapiens (Human)
Function
Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
UniProt ID
Q9HCN6
UniProt Entry
GPVI_HUMAN
PFam
PF13895
Gene ID
51206
Sequence
MSPSPTALFCLGLCLGRVPAQSGPLPKPSLQALPSSLVPLEKPVTLRCQGPPGVDLYRLE
KLSSSRYQDQAVLFIPAMKRSLAGRYRCSYQNGSLWSLPSDQLELVATGVFAKPSLSAQP
GPAVSSGGDVTLQCQTRYGFDQFALYKEGDPAPYKNPERWYRASFPIITVTAAHSGTYRC
YSFSSRDPYLWSAPSDPLELVVTGTSVTPSRLPTEPPSPVAEFSEATAELTVSFTNEVFT
TETSRSITASPKESDSPAGPARQYYTKGNLVRICLGAVILIILAGFLAEDWHSRRKRLRH
RGRAVQRPLPPLPPLPLTRKSNGGQDGGRQDVHSRGLCS
Sequence Length
339
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Fab Glenzocimab Phase II Inhibitor N.A. Stroke [ICD-11: 8B20]; SARS-CoV-2 infection (COVID-19) [ICD-11: XN109]
SBP Info
 		[1]
Nanobody anti-GPVI Nb2 Research Inhibitor Kd: 0.58 nM Research tool
SBP Info
 		[2]
References
1 Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen-Induced Platelet Aggregation. J Clin Pharmacol. 2020 Sep;60(9):1198-1208.
2 Structural characterization of a novel GPVI-nanobody complex reveals a biologically active domain-swapped GPVI dimer. Blood. 2021 Jun 17;137(24):3443-3453.