Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00333)
BTS Name
Interleukin-13
Synonyms
IL-13
BTS Type
Protein
Family
IL-4/IL-13 family
Gene Name
IL13
Organism
Homo sapiens (Human)
Function
Cytokine Inhibits inflammatory cytokine production Synergizes with IL2 in regulating interferon-gamma synthesis May be critical in regulating inflammatory and immune responses Positively regulates IL31RA expression in macrophages (By similarity).
UniProt ID
P35225
UniProt Entry
IL13_HUMAN
PFam
PF03487
Gene ID
3596
Sequence
MHPLLNPLLLALGLMALLLTTVIALTCLGGFASPGPVPPSTALRELIEELVNITQNQKAP
LCNGSMVWSINLTAGMYCAALESLINVSGCSAIEKTQRMLSGFCPHKVSAGQFSSLHVRD
TKIEVAQFVKDLLLHLKKLFREGRFN
Sequence Length
146
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DARPin anti-IL-13 clone 6G9 Research Blocker N.A. Asthma [ICD-11: CA23]
SBP Info
 		[1]
Fab Abrezekimab Phase I Binder N.A. Asthma [ICD-11: CA23]
SBP Info
 		[2]
References
1 Conformational flexibility of an anti-IL-13 DARPin. Protein Eng Des Sel. 2017 Jan;30(1):31-37.
2 Soluble ligands as drug targets. Nat Rev Drug Discov. 2020 Oct;19(10):695-710. doi: 10.1038/s41573-020-0078-4.