Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00302) | ||||||
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| BTS Name |
Apical membrane antigen 1
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| Synonyms |
Merozoite surface antigen
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| BTS Type |
Protein
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| Family |
Apicomplexan parasites AMA1 family
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| Organism |
Plasmodium falciparum (isolate 3D7)
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| Function |
Involved in parasite invasion of erythrocytes.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRKLYCVLLLSAFEFTYMINFGRGQNYWEHPYQNSDVYRPINEHREHPKEYEYPLHQEHT
YQQEDSGEDENTLQHAYPIDHEGAEPAPQEQNLFSSIEIVERSNYMGNPWTEYMAKYDIE EVHGSGIRVDLGEDAEVAGTQYRLPSGKCPVFGKGIIIENSNTTFLTPVATGNQYLKDGG FAFPPTEPLMSPMTLDEMRHFYKDNKYVKNLDELTLCSRHAGNMIPDNDKNSNYKYPAVY DDKDKKCHILYIAAQENNGPRYCNKDESKRNSMFCFRPAKDISFQNYTYLSKNVVDNWEK VCPRKNLQNAKFGLWVDGNCEDIPHVNEFPAIDLFECNKLVFELSASDQPKQYEQHLTDY EKIKEGFKNKNASMIKSAFLPTGAFKADRYKSHGKGYNWGNYNTETQKCEIFNVKPTCLI NNSSYIATTALSHPIEVENNFPCSLYKDEIMKEIERESKRIKLNDNDDEGNKKIIAPRIF ISDDKDSLKCPCDPEMVSNSTCRFFVCKCVERRAEVTSNNEVVVKEEYKDEYADIPEHKP TYDKMKIIIASSAAVAVLATILMVYLYKRKGNAEKYDKMDEPQDYGKSNSRNDEMLDPEA SFWGEEKRASHTTPVLMEKPYY |
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| Sequence Length |
622
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| VNAR anti-AMA1 12Y-2 | Research | Inhibitor | Kd: 300 nM | Malaria [ICD-11: 1F4Z] | [1], [2] | |
| VNAR anti-AMA1 14I-1 | Research | Inhibitor | Kd: 5 nM | Malaria [ICD-11: 1F4Z] | [1] | |
| VNAR anti-AMA1 14I1-M15 | Research | Inhibitor | Kd: 4.7 nM | Malaria [ICD-11: 1F4Z] | [1] | |