Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00298) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Beta-lactamase inhibitory protein
|
|||||
| Synonyms |
BLIP
|
|||||
| BTS Type |
Protein
|
|||||
| Organism |
Streptomyces clavuligerus
|
|||||
| Function |
Inhibits a wide variety of beta lactamases.
|
|||||
| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRTVGIGAGVRRLGRAVVMAAAVGGLVLGSAGASNAAGVMTGAKFTQIQFGMTRQQVLDI
AGAENCETGGSFGDSIHCRGHAAGDYYAYATFGFTSAAADAKVDSKSQEKLLAPSAPTLT LAKFNQVTVGMTRAQVLATVGQGSCTTWSEYYPAYPSTAGVTLSLSCFDVDGYSSTGFYR GSAHLWFTDGVLQGKRQWDLV |
|||||
| Sequence Length |
201
|
|||||
| Synthetic Binding Protein (SBP) Targeting This BTS |
|---|
| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| TEM1-beta-lactamase based binder anti-BLIP E110G/E239G mutant | Research | Binder | Kd: 0.18 nM | Research tool | [1] | |
| TEM1-beta-lactamase based binder anti-BLIP K51R/E110G mutant | Research | Binder | Kd: 0.26 nM | Research tool | [1] | |
| TEM1-beta-lactamase based binder anti-BLIP V30Q/H112R/T128S/E171K/E197K mutant | Research | Binder | Kd: 0.27 nM | Research tool | [1] | |