General Information of Binding Target of SBP (BTS) (ID: ST00290)
BTS Name
Hemolysin E
Synonyms
Cytotoxin ClyA; Silent hemolysin SheA
BTS Type
Protein
Family
Hemolysin E family
Gene Name
hlyE
Organism
Salmonella paratyphi A (strain ATCC 9150 / SARB42)
Function
Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells (By similarity).
UniProt ID
Q93RR6
UniProt Entry
HLYE_SALPA
PFam
PF06109
Sequence
MTGIFAEQTVEVVKSAIETADGALDFYNKYLDQVIPWKTFDETIKELSRFKQEYSQEASV
LVGDIKVLLMDSQDKYFEATQTVYEWCGVVTQLLSAYILLFDEYNEKKASAQKDILIRIL
DDGVNKLNEAQKSLLGSSQSFNNASGKLLALDSQLTNDFSEKSSYFQSQVDRIRKEAYAG
AAAGIVAGPFGLIISYSIAAGVIEGKLIPELNDRLKAVQNFFTSLSVTVKQANKDIDAAK
LKLATEIAAIGEIKTETETTRFYVDYDDLMLSLLKGAAKKMINTCNEYQQRHGKKTLLEV
PDI
Sequence Length
303
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
scFv anti-HlyE A11 Research Binder N.A. Typhoid fever [ICD-11: 1A07]
SBP Info
[1]
scFv anti-HlyE C2 Research Binder N.A. Typhoid fever [ICD-11: 1A07]
SBP Info
[1]
References
1 Delineation of B-cell Epitopes of Salmonella enterica serovar Typhi Hemolysin E: Potential antibody therapeutic target. Sci Rep. 2017 May 19;7(1):2176.