Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00283) | ||||||
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| BTS Name |
Prostate-specific antigen
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| Synonyms |
PSA; EC 3.4.21.77; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase
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| BTS Type |
Protein
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| Family |
Peptidase S1 family;
Kallikrein subfamily |
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| Gene Name |
KLK3
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| Organism |
Homo sapiens (Human)
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| Function |
Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAVCGGVLVHPQWV
LTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNRFLRPGDDSSHD LMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPKKLQCVDLHVIS NDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITSWGSEPCALPERP SLYTKVVHYRKWIKDTIVANP |
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| Sequence Length |
261
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-PSA clone C12 | Research | Binder | Kd: 2.6 nM | Research tool | [1] | |
| Nanobody anti-PSA clone N8 | Research | Binder | Kd: 1.6 nM | Research tool | [1] | |
| scFv anti-PSA M-PSA1 | Research | Binder | Kd: 5.3 nM | Research tool | [2] | |
| References |
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