Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00230) | ||||||
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| BTS Name |
Sodium- and chloride-dependent glycine transporter 1
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| Synonyms |
GlyT-1; GlyT1; Solute carrier family 6 member 9
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| BTS Type |
Protein
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| Family |
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family;
SLC6A9 subfamily |
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| Gene Name |
SLC6A9
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| Organism |
Homo sapiens (Human)
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| Function |
Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI |
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| Sequence Length |
706
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Nanobody anti-GlyT1 clone 1 | Research | Binder | Kd: 307 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 2 | Research | Binder | Kd: 2520 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 3 | Research | Binder | Kd: 1.5 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 4 | Research | Binder | Kd: 476.1 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 5 | Research | Binder | Kd: 81.9 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 6 | Research | Binder | Kd: 0.49 nM | Tools for the conformational trapping of membrane proteins | [1] | |
| Nanobody anti-GlyT1 clone 7 | Research | Binder | Kd: 9.2 nM | Tools for the conformational trapping of membrane proteins | [1] | |