Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00209)
BTS Name
Growth/differentiation factor 8
Synonyms
GDF-8; Myostatin
BTS Type
Protein
Family
TGF-beta family
Gene Name
MSTN
Organism
Homo sapiens (Human)
Function
Acts specifically as a negative regulator of skeletal muscle growth.
UniProt ID
O14793
UniProt Entry
GDF8_HUMAN
PFam
PF00019 ; PF00688
Gene ID
2660
Sequence
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI
LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT
MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM
KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT
FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA
PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII
YGKIPAMVVDRCGCS
Sequence Length
375
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody Talditercept alfa Phase III Inhibitor Kd: 0.17 nM Duchenne muscular dystrophy [ICD-11: 8C70.1]; Cachexia [ICD-11: MG20.Z]
SBP Info
 		[1], [2]
References
1 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.
2 DRUGBANK online. Talditercept alfa