Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00206) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Protein-S-isoprenylcysteine O-methyltransferase
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| Synonyms |
EC 2.1.1.100
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| BTS Type |
Protein
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| Family |
Class VI-like SAM-binding methyltransferase superfamily;
Isoprenylcysteine carboxyl methyltransferase family |
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| Gene Name |
ICMT
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| Organism |
Tribolium castaneum (Red flour beetle)
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| Function |
Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MLSPAGKISLQSFTGSSLVFFVICMFNHYYGITNLVVNTLIVFFYAVNVYFFLKFFYNEF
AFAIAIRAAFLGLVLVLGLYIKLVAPPNIQIFGGYMSVMALFHYSEFLAIAIVQPKQVST DSFVINHSPQYTIAAVSSWVEFFIETYFFPGLKEIHWLSNIGLCVCILGEVLRKTAILTA GSNFNHLVQCEKSSDHVLVTHGVYAWFRHPSYVGWFYWSIGTQIILINPLCIPAYTLASW MFFKERIYIEESMLLSFFGQQYCDYQQQVGTGIPFIEGYKI |
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| Sequence Length |
281
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Monobody anti-ICMT MB-15 | Research | Binder | N.A. | Cancers [ICD-11: 2D4Z] | [1] | |