Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00182)
BTS Name
Carcinoembryonic antigen-related cell adhesion molecule 6
Synonyms
Non-specific crossreacting antigen; Normal cross-reacting antigen; CD antigen CD66c
BTS Type
Protein
Family
Immunoglobulin superfamily;
CEA family
Gene Name
CEACAM6
Organism
Homo sapiens (Human)
Function
Cell surface glycoprotein that plays a role in cell adhesion and tumor progression Intercellular adhesion occurs in a calcium- and fibronectin-independent manner Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 Heterophilic interaction with CEACAM8 occurs in activated neutrophils Plays a role in neutrophil adhesion to cytokine-activated endothelial cells Plays a role as an oncogene by promoting tumor progression; positively regulates cell migration, cell adhesion to endothelial cells and cell invasion Also involved in the metastatic cascade process by inducing gain resistance to anoikis of pancreatic adenocarcinoma and colorectal carcinoma cells
UniProt ID
P40199
UniProt Entry
CEAM6_HUMAN
PFam
PF13895 ; PF07686
Gene ID
4680
Sequence
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ
NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWV
NGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDGP
TISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQ
AHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI
Sequence Length
344
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Human VH dAb anti-CEACAM6 VH428-3 Research Binder Kd: 290 nM Research tool
SBP Info
 		[1]
Human VH dAb anti-CEACAM6 VHB82(SS)-2 Research Binder Kd: 245 nM Research tool
SBP Info
 		[1]
VL dAb anti-CEACAM6 VL383(SS)-1 Research Binder Kd: 454 nM Research tool
SBP Info
 		[1]
References
1 Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human V H/V L Single-Domain Antibodies from In Vitro Display Libraries. Front Immunol. 2017 Dec 12;8:1759.