Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00174) | ||||||
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| BTS Name |
Interleukin-18
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| Synonyms |
IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma
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| BTS Type |
Protein
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| Family |
IL-1 family
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| Gene Name |
IL18
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| Organism |
Homo sapiens (Human)
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| Function |
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable)
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MAAEPVEDNCINFVAMKFIDNTLYFIAEDDENLESDYFGKLESKLSVIRNLNDQVLFIDQ
GNRPLFEDMTDSDCRDNAPRTIFIISMYKDSQPRGMAVTISVKCEKISTLSCENKIISFK EMNPPDNIKDTKSDIIFFQRSVPGHDNKMQFESSSYEGYFLACEKERDLFKLILKKEDEL GDRSIMFTVQNED |
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| Sequence Length |
193
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Fab anti-IL-18 h18-108 | Research | Inhibitor | Kd: 3.7 nM | Inflammation [ICD-11: 1A00-CA43.1] | ||
| scFv anti-IL-18 clone 108 | Research | Inhibitor | Kd: 50 nM | Inflammation [ICD-11: 1A00-CA43.1] | [1] | |
| scFv anti-IL-18 clone 40 | Research | Blocker | N.A. | Inflammation [ICD-11: 1A00-CA43.1] | [1] | |
| scFv anti-IL-18 clone 64 | Research | Blocker | N.A. | Inflammation [ICD-11: 1A00-CA43.1] | [1] | |