Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00157)
BTS Name
CD99 antigen
Synonyms
1.20E+08; E2 antigen; Protein MIC2; T-cell surface glycoprotein E2; CD antigen CD99
BTS Type
Protein
Family
CD99 family
Gene Name
CD99
Organism
Homo sapiens (Human)
Function
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
UniProt ID
P14209
UniProt Entry
CD99_HUMAN
PFam
PF12301
Gene ID
4267
Sequence
MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVV
DGENDDPRPPNPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEE
ADAPGVIPGIVGAVVVAVAGAISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQR
TLLEK
Sequence Length
185
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Diabody anti-CD99 C7 Research Binder N.A. Ewing sarcoma [ICD-11: XH8KJ8]
SBP Info
 		[1]
References
1 Process development of a human recombinant diabody expressed in E. coli: engagement of CD99-induced apoptosis for target therapy in Ewing's sarcoma. Appl Microbiol Biotechnol. 2016 May;100(9):3949-63.