General Information of Binding Target of SBP (BTS) (ID: ST00151)
BTS Name
26S proteasome complex subunit SEM1
BTS Type
Protein
Family
DSS1/SEM1 family
Gene Name
SEM1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function
Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation.
UniProt ID
O94742
UniProt Entry
SEM1_YEAST
PFam
PF05160
Gene ID
851967
Sequence
MSTDVAAAQAQSKIDLTKKKNEEINKKSLEEDDEFEDFPIDTWANGETIKSNAVTQTNIW
EENWDDVEVDDDFTNELKAELDRYKRENQ
Sequence Length
89
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Designed TPR protein anti-Dss1 T-Mods Research Inhibitor Kd: 175000 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
References
1 Designed proteins to modulate cellular networks. ACS Chem Biol. 2010 Jun 18;5(6):545-52.