Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00143)
BTS Name
Cadherin-3
BTS Type
Protein
Gene Name
CDH3
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Function
Cadherins are calcium-dependent cell adhesion proteins.
UniProt ID
A0A2K5WPN9
UniProt Entry
A0A2K5WPN9_MACFA
PFam
PF00028 ; PF01049
Sequence
MGLPRGPLACLLLVQVCWLQCAASEPCRAIFGEAEVTLEAGGAEQEPSQALGKVFMGCPG
QEPALFSTVNDDFTVQNGETVQDRKSLKERNPLKIFPSKRILRRHKRDWVVAPISVPENG
KGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEKETGWLLLNKPLDREEIAK
YELFGHAVSENGASVEDPMNISIIVTDQNDHKPKFTQDTFRGSVLEGVLPGTSVMQVTAT
DEDDAIHTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISVISSGLDREKVPEYTLTIQA
TDMDGDGSTTTAVAVVEILDANDNAPVFDPQKYESHVPENAVGHEVQRLTVTDLDAPNSP
AWRATYLIVGGDDGDHFTIATHPESNQGILTTRKGLDFEAKNQHTLYVEVTNEAPFVLKL
PTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTGEAVCVYTAKDPDKENQKISYRILR
DPAGWLAMDPDSGQVTVAGTLDREDERFVRNNIYEVMVLAVDNGSPPTTGTGTLLLTLID
VNDHGPVPEPREITICNQSPESQVLNITDKDLSPHTSPFQAQLTDDSDIYWMAEVNEKDD
TVVLSLKKFLKQDTYDVHLSLSDHGNKEQLTVIRATVCDCHGHVEKCPDPWKGGFILPVL
GAVLSLLLLLLVLLLLVRKKRKVKEPLLLPEDDTRDNVFYYGEEGGGEEDQDYDITQLHR
GLEARPEVVLRNDVAPTFISTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDSLLVF
DYEGSGSDAASLSSLTSSTSDQDQDYDYLNEWGSRFKKLADMYGGGDDD
Sequence Length
829
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DART anti-cadherin/CD3 153 Research Binder Kd: 0.23 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
DART anti-cadherin/CD3 20 Research Binder Kd: 2.0 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
DART anti-cadherin/CD3 30 Research Binder Kd: 1.4 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
DART anti-cadherin/CD3 33 Research Binder Kd: 46.4 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
DART anti-cadherin/CD3 34 Research Binder Kd: 129.3 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
DART anti-cadherin/CD3 35 Research Binder Kd: 43.4 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[1]
References
1 Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer. Antibodies (Basel). 2016 Mar 4;5(1):6.