Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00135)
BTS Name
Cathepsin B
Synonyms
EC 3.4.22.1; Cathepsin B1
BTS Type
Protein
Family
Peptidase C1 family
Gene Name
Ctsb
Organism
Mus musculus (Mouse)
Function
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen Has also been implicated in tumor invasion and metastasis (By similarity).
UniProt ID
P10605
UniProt Entry
CATB_MOUSE
PFam
PF00112 ; PF08127
Gene ID
13030
Sequence
MWWSLILLSCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNFYNVDISYLKKLCG
TVLGGPKLPGRVAFGEDIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDR
TCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCL
PYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIM
AEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSW
NLDWGDNGFFKILRGENHCGIESEIVAGIPRTDQYWGRF
Sequence Length
339
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DARPin anti-Cathepsin-B clone 8h6 Research Inhibitor Kd: 0.2 nM Non-invasive in vivo imaging of tumour-associated cathepsin B
SBP Info
 		[1], [2]
References
1 New Kid on the Block. Theranostics. 2017 Jul 30;7(11):2965-2967.
2 Non-invasive in vivo imaging of tumour-associated cathepsin B by a highly selective inhibitory DARPin. Theranostics. 2017 Jul 8;7(11):2806-2821.