Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00134) | ||||||
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| BTS Name |
Cathepsin B
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| Synonyms |
EC 3.4.22.1; APP secretase; APPS; Cathepsin B1
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| BTS Type |
Protein
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| Family |
Peptidase C1 family
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| Gene Name |
CTSB
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| Organism |
Homo sapiens (Human)
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| Function |
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins Cleaves matrix extracellular phosphoglycoprotein MEPE Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI |
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| Sequence Length |
339
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| DARPin anti-Cathepsin-B clone 81 | Research | Inhibitor | Kd: 4.1 nM | Non-invasive in vivo imaging of tumour-associated cathepsin B | [1], [2] | |
| DARPin anti-Cathepsin-B clone 8h6 | Research | Inhibitor | Kd: 0.031 nM | Non-invasive in vivo imaging of tumour-associated cathepsin B | [1], [2] | |