Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00133) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Interleukin-4
|
|||||
| Synonyms |
IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra
|
|||||
| BTS Type |
Protein
|
|||||
| Family |
IL-4/IL-13 family
|
|||||
| Gene Name |
IL4
|
|||||
| Organism |
Homo sapiens (Human)
|
|||||
| Function |
Participates in at least several B-cell activation processes as well as of other cell types It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity). Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).
|
|||||
| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAAS
KNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGL NSCPVKEANQSTLENFLERLKTIMREKYSKCSS |
|||||
| Sequence Length |
153
|
|||||
| Synthetic Binding Protein (SBP) Targeting This BTS |
|---|
| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-IL-4 clone 44 | Research | Binder | Kd: 0.013-0.021 nM | Tools for inducing conformational change in human IL-4 upon | [1] | |