General Information of Binding Target of SBP (BTS) (ID: ST00124)
BTS Name
Neurotensin receptor type 1
Synonyms
NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH
BTS Type
Protein
Family
G-protein coupled receptor 1 family;
Neurotensin receptor subfamily;
NTSR1 sub-subfamily
Gene Name
Ntsr1
Organism
Rattus norvegicus (Rat)
Function
G-protein coupled receptor for the tridecapeptide neurotensin (NTS) Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis (By similarity).
UniProt ID
P20789
UniProt Entry
NTR1_RAT
PFam
PF00001
Gene ID
366274
Sequence
MHLNSSVPQGTPGEPDAQPFSGPQSEMEATFLALSLSNGSGNTSESDTAGPNSDLDVNTD
IYSKVLVTAIYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLA
MPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTL
MSRSRTKKFISAIWLASALLAIPMLFTMGLQNRSGDGTHPGGLVCTPIVDTATVKVVIQV
NTFMSFLFPMLVISILNTVIANKLTVMVHQAAEQGRVCTVGTHNGLEHSTFNMTIEPGRV
QALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYV
SSAINPILYNLVSANFRQVFLSTLACLCPGWRHRRKKRPTFSRKPNSMSSNHAFSTSATR
ETLY
Sequence Length
424
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DARPin anti-NTSR1 D14 Research Binder Kd: 112 nM Tools as an alternative binding molecule for co-crystallization
SBP Info
[1]
DARPin anti-NTSR1 P28 Research Binder Kd: 75 nM Tools as an alternative binding molecule for co-crystallization
SBP Info
[1]
DARPin anti-NTSR1 P4 Research Binder Kd: 58 nM Tools as an alternative binding molecule for co-crystallization
SBP Info
[1]
References
1 Selection and characterization of DARPins specific for the neurotensin receptor 1. Protein Eng Des Sel. 2009 Jun;22(6):357-66.