Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00123)
BTS Name
Caspase-7
Synonyms
CASP-7; EC 3.4.22.60; Apoptotic protease Mch-3; CMH-1; ICE-like apoptotic protease 3; ICE-LAP3
BTS Type
Protein
Family
Peptidase C14A family
Gene Name
CASP7
Organism
Homo sapiens (Human)
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.
UniProt ID
P55210
UniProt Entry
CASP7_HUMAN
Gene ID
840
Sequence
MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
Sequence Length
303
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
DARPin anti-CASP-7 C7_16 Research Inhibitor Kd: 44 nM Research tool
SBP Info
 		[1]
DARPin anti-CASP-7 D7.18 Research Inhibitor Kd: 144 nM Research tool
SBP Info
 		[2]
DARPin anti-CASP-7 D7.43 Research Inhibitor Kd: 24.7 nM Research tool
SBP Info
 		[2]
References
1 Design, construction, and characterization of a second-generation DARP in library with reduced hydrophobicity. Protein Sci. 2013 Sep;22(9):1239-57.
2 Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise. Biochem J. 2014 Jul 15;461(2):279-90.