Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00105)
BTS Name
Proto-oncogene Mas
BTS Type
Protein
Family
G-protein coupled receptor 1 family
Gene Name
MAS1
Organism
Homo sapiens (Human)
Function
Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.
UniProt ID
P04201
UniProt Entry
MAS_HUMAN
PFam
PF00001
Gene ID
4142
Sequence
MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFR
MRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGL
YLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHS
RNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIF
AMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLT
RAFKDEMQPRRQKDNCNTVTVETVV
Sequence Length
325
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Cyclotide anti-MAS1 MCo-AT1-7 Research Activator N.A. Cancers [ICD-11: 2D4Z]; Myocardial infarction [ICD-11: BA41]
SBP Info
 		[1]
References
1 Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity. Molecules. 2016 Jan 26;21(2):152.