Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00093) | ||||||
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| BTS Name |
Tumor necrosis factor receptor superfamily member 17
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| Synonyms |
B-cell maturation protein; CD antigen CD269
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| BTS Type |
Protein
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| Gene Name |
TNFRSF17
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| Organism |
Homo sapiens (Human)
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| Function |
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCL
GLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLE YTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKS ISAR |
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| Sequence Length |
184
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| BiTE Pacanalotamab | Phase I | Binder | N.A. | Multiple myeloma [ICD-11: 2A83.Y] | [1], [2] | |
| BiTE Pavurutamab | Phase I; Suspended | Inhibitor | N.A. | Prostate cancer [ICD-11: 2C82.Z]; Multiple myeloma [ICD-11: 2A83.Y] | [3] | |
| References |
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