General Information of Binding Target of SBP (BTS) (ID: ST00093)
BTS Name
Tumor necrosis factor receptor superfamily member 17
Synonyms
B-cell maturation protein; CD antigen CD269
BTS Type
Protein
Gene Name
TNFRSF17
Organism
Homo sapiens (Human)
Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
UniProt ID
Q02223
UniProt Entry
TNR17_HUMAN
PFam
PF09257
Gene ID
608
Sequence
MLQMAGQCSQNEYFDSLLHACIPCQLRCSSNTPPLTCQRYCNASVTNSVKGTNAILWTCL
GLSLIISLAVFVLMFLLRKINSEPLKDEFKNTGSGLLGMANIDLEKSRTGDEIILPRGLE
YTVEECTCEDCIKSKPKVDSDHCFPLPAMEEGATILVTTKTNDYCKSLPAALSATEIEKS
ISAR
Sequence Length
184
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
BiTE Pacanalotamab Phase I Binder N.A. Multiple myeloma [ICD-11: 2A83.Y]
SBP Info
[1], [2]
BiTE Pavurutamab Phase I; Suspended Inhibitor N.A. Prostate cancer [ICD-11: 2C82.Z]; Multiple myeloma [ICD-11: 2A83.Y]
SBP Info
[3]
References
1 The BiTE (bispecific T-cell engager) platform: Development and future potential of a targeted immuno-oncology therapy across tumor types. Cancer. 2020 Jul 15;126(14):3192-3201.
2 B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches. Leukemia. 2020 Apr;34(4):985-1005.
3 Amgen. Product Development Pipeline. 2021.