Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00084) | ||||||
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| BTS Name |
Growth factor receptor-bound protein 2
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| Synonyms |
Adapter protein GRB2; Protein Ash; SH2/SH3 adapter GRB2
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| BTS Type |
Protein
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| Family |
GRB2/sem-5/DRK family
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| Gene Name |
GRB2
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| Organism |
Homo sapiens (Human)
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| Function |
Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.; [Isoform 2]: Does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV |
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| Sequence Length |
217
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Bicyclic peptide anti-Grb2 clone 1 | Research | Inhibitor | N.A. | Tools for promoting phosphotyrosine mimicry and cellular uptake | [1] | |