General Information of Binding Target of SBP (BTS) (ID: ST00017)
BTS Name
Apolipoprotein A-I
Synonyms
Apo-AI; ApoA-I; Apolipoprotein A1
BTS Type
Protein
Family
Apolipoprotein A1/A4/E family
Gene Name
APOA1
Organism
Homo sapiens (Human)
Function
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
UniProt ID
P02647
UniProt Entry
APOA1_HUMAN
PFam
PF01442
Gene ID
335
Sequence
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
GLLPVLESFKVSFLSALEEYTKKLNTQ
Sequence Length
267
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affibody anti-Apo-A-1 clone 24:4 Research Binder Kd: 1000 nM Tools for specific binding to different target proteins
SBP Info
[1]
References
1 Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. Nat Biotechnol. 1997 Aug;15(8):772-7.