Details of the SBP-Target Complex
| Synthetic Binding Protein (SBP)-Target Complex | ||||||
|---|---|---|---|---|---|---|
| Complex Name | scFv Licaminlimab with TNF-alpha | [1] | ||||
| SBP | Target | |||||
| scFv Licaminlimab | Tumor necrosis factor (TNF-alpha) | |||||
|
3D Structure
Annotation of Structure
SBP Target |
||||||
| Click to Save PDB File | Click to Save PSE File | |||||
| Statistics of The Docking Results |
|
|||||
| Complex Method | ZDOCK + RosettaDock | |||||
| Complex Quality | High Quality | |||||
| SBP Structure Type | Computationally Modelled Structure | |||||
| Target Structure Type | Experimentally Validated Structure | |||||
| General Information of SBP (ID: SBP003382) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv Licaminlimab
|
|||||
| Highest Status | Phase II | |||||
| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| General Information of Binding Target of SBP (BTS) (ID: ST00003) | ||||||
|---|---|---|---|---|---|---|
| BTS Name |
Tumor necrosis factor
|
|||||
| BTS Type |
Protein
|
|||||
| Family |
Tumor necrosis factor family
|
|||||
| UniProt Entry | ||||||
| Expanding Sequence Space for This Complex |
|---|
| Sequence | ProMPNN Score |
Sequence Recovery |
Predicted Solution |
Instability Index (II) |
Molecular Weight |
|---|---|---|---|---|---|
|
AKNVVTQSPKSLSAPIGATVTISCTTSQPVLFGNDMSWYKQKPGKPPQLIIYNASTLAPG
VSSRYSGSGSGNSFTLTISSLQCEDEATYYCLGRFDTGDRFQFGQGTKLTVEGCEGAPAA AAAAAPVPASGAPPKSITETGGSVAPGGSLTLSCTASGFKISDVEWVAWVRQAPGKGLEW VGSIHGSSDIPPQYSSAAKGRFTLSRDLANNTVYLHMSNLQPEDTATYYCAVLDKSYNAF SLWGQGTQVTVAA |
0.7946 | 0.5929 | 0.484 | 38.49 | 26.4 kDa |
|
PTNVVTQSPSSITKAIGETVTLSCTTSQPVVNNNDMSWYKQKPGQPPQLLIYKASTLAPG
VSSRYSGSGSGNSFTLTISSVQCEDEATYYCQGRFDTGDRIQFGQGTKLTVEGCEGAPAL ELPLLPLPLSPVPPQSLTETGGSVAPGGSLTLTCTASGFKIADQEWVAWVRQAPGQGLQW VGAIHGSSDIPPLYSAAFRGRFTLSRDVANNTVYLHMSNLTPADTATYYCAVLDSSYNAF SLWGSGTQLTVAA |
0.7834 | 0.5573 | 0.472 | 42.2 | 26.7 kDa |
|
AKNVVTQSPTEISAKIGETVTITCTASQPVVNNNDMSWYKQKPGQPPQLLIYKASTRAPG
VSSRYSGSGSGNSFTLTISSVQCEDEATYYCLGRFDTGDRFVFGQGTKLTVLGCDGAAAA AAAAAAAPASGAPPKSITETGGSVAPGGSITLTCTASGFKIADEEWYAWVRQAPGQGLEW VGAIHGATDIPPVYSAAFKGRFTLSRDLANNTVYLHMTNLTAADTATYYCAVLDPAYNAF SLWGSGTQLTVAA |
0.777 | 0.5692 | 0.492 | 30.39 | 26.3 kDa |
|
AKNTVTQSPSSLTAAVGATVVISCTASQNVLFNNDWSWYKQKPGQPPQLLIYKASKRAPG
VSSRYSGSGSGNSFTLTISSLQCEDEATYYCQGRFDTGDRWVFGQGTKLTVSGCEGAAAA AAAAAAAAASGTPPQSLTETGGSVAPGGSITLSCKASGFKLADQEWVAWVRQAPGQGLQW VGSIHGGSDIPPLYSSDFKGRYTLSRDLAKNTSYLHMTNLTPEDTATYYCAVLDKDYNAF SLWGEGTLLTVAA |
0.7762 | 0.5731 | 0.499 | 32.87 | 26.5 kDa |
|
TTNTVTQSPLSLSAAVGATVTITCTTSQPVLFNNDMSWYKQKPGQPPQLLIYKASTLAPG
VSSRYSGSGSGSSFTLTISALQCGDEATYYCQARFDTGDRVVFGQGTKLTVSGCAGAPAA AAPAAPAPATGVPPKSLTETGGSVAPGGSITLSCKASGFKISDVEWVAWYRQAPGQGLQY VGSIHGARDIPPVYSSAFSGKYTLSRDLANNTTYLNMTNLTPADTATYYCAVLDPETNAF SLWGAGTQVTVAA |
0.7699 | 0.5534 | 0.534 | 31.65 | 26.1 kDa |
| Sequence Logos | |||||
|---|---|---|---|---|---|
 | |||||
| Multiple Sequence Alignments | |||||
 |