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SBP-Target Complex
2025 Update
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Expanding SBP Space
2025 Update
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SBP-like Protein Scaffolds
2025 Update
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against All SBPs in SYNBIP
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against All Binding Targets
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COVID-related Studies
What is NEW in SYNBIP Database 2.0
A major update was conducted to our SYNBIP, and four types of data were updated to its 2.0 version. First, the epitopes of representative SBPs from each scaffold were structurally mapped by identifying structures of corresponding SBPs in complex with their targets. Those complex structures come from experimentally determined coordinates provided in PDB or computationally predicted models constructed using well-known protocols. Second, the sequence space of existing SBPs were largely expanded by a robust and powerful deep learning-based framework PoteinMPNN together with the comprehensive protein properties analysis. Third, driven by the structure-based protein comparison method Foldseek, SBP-like protein scaffolds mining was performed, providing a unique promising parent protein scaffolds dataset to support SBP related studies. Finally, routine updates were performed on this database, with over 153 new SBPs added.
Learn more about SYNBIP 2.0 >
Learn more about SYNBIP 2.0 >