Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003621) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
BiTE anti-PSMA 5D3-alphaCD3
|
|||||
| Synonyms |
BiTE 5D3-alphaCD3
|
|||||
| Molecular Weight | 57.1 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Schneiders S2 cells | |||||
| Highest Status | Research | |||||
| Sequence Length | 536 | |||||
| SBP Sequence |
>BiTE anti-PSMA 5D3-alphaCD3
MKLCILLAVVAFVGLSLGRSEVQLQQSGPELVKPGASVKISCKTSGYAFNTSWMNWVKQR PGQGLEWIGRIYPGDGDTNYNGKEKGKATLTADKSSSTAHMHLSSLTSVDSAVYFCARGE WYLYYEDYWGQGTTLTVSSGGSGGGGSGGGGSGGGGSDIQMTQTTSSLSASLGDRVTISC SASQGINNELTWYQQKPDGTLKLLIYYTSSLHSGVPSRESGSGSGTDYSLTIRNLEPEDI ATYYCQQYSNLPFTEGGGTKVEIKRASIRSGGSGGSGGGPLSDIKLQQSGAELARPGASV KMSCKTSGYTFTRYTMHWVKQRPGQGLEWIGYINPSRGYTNYNQKFKDKATLTTDKSSST AYMQLSSLTSEDSAVYYCARYYDDHYCLDYWGQGTTLTVSSVEGGSGGSGGSGGSGGVDD IQLTQSPAIMSASPGEKVTMTCRASSSVSYMNWYQQKSGTSPKRWIYDTSKVASGVPYRE SGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPLTEGAGTKLELKALSAWSHPQFE |
|||||
| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS018 | [1] | ||||
| Scaffold Name | BiTE | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Glutamate carboxypeptidase 2 | binder | Prostate cancer [ICD-11: 2C82.Z] | N.A. | Czech Academy of Sciences | [1] | |