General Information of Synthetic Binding Protein (SBP) (ID: SBP003474)
SBP Name
Nanobody anti-XKR9 Sb1
Synonyms
Sb1
Molecular Weight 13.5 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli WK6
Selection Method Phage display
Highest Status Research
PDB ID 7P14; 7P16
Sequence Length 124
SBP Sequence
>Nanobody anti-XKR9 Sb1
QVQLVESGGGSVQAGGSLRLSSAASGNIADIYYLGWFRQAPGKEREGVAALITYNGRTYY
ADSVKGRFTVSLDNAKNTVYLQMNSLKPEDTALYYSAAAYNGLIAAPLKVTRYWYWGQGT
QVTV
3D Structure
Experimentally Validated Structure
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Template Name VHH D2-L24
Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
XK-related protein
BTS Info
Binder Research tool N.A. University of Zurich [1]
References
1 Cryo-EM structures of the caspase-activated protein XKR9 involved in apoptotic lipid scrambling. Elife. 2021 Jul 15;10:e69800.