Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003460)
SBP Name
Nanobody anti-Fab
Synonyms
Nanobody anti-Fab
Molecular Weight 13.2 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21
Highest Status Research
PDB ID 6WW2; 7JHG; 7PHP; 7PIJ
Sequence Length 121
SBP Sequence
>Nanobody anti-Fab
QVQLQESGGGLVQPGGSLRLSCAASGRTISRYAMSWFRQAPGKEREFVAVARRSGDGAFY
ADSVQGRFTVSRDDAKNTVYLQMNSLKPEDTAVYYCAIDSDTFYSGSYDYWGQGTQVTVS
S
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1] , [2]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Anti-BRIL Fab
BTS Info
Binder Research tool N.A. Stanford University School of Medicine [1] , [2]
References
1 Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. Elife. 2020 Aug 7;9:e58464.
2 Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021 Jul 23;373(6553):413-419.