Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003384) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv Radretumab
|
|||||
| Synonyms |
TAB-193; L19-131 I; L19-I131; L19-SIP
|
|||||
| Molecular Weight | 38.6 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Highest Status | Phase II; Discontinued | |||||
| Sequence Length | 357 | |||||
| SBP Sequence |
>scFv Radretumab
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFSMSWVRQAPGKGLEWVSSISGSSGTTYY ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPFPYFDYWGQGTLVTVSSGDGS SGGSGGASEIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIYYA SSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQTGRIPPTFGQGTKVEIKSGGS GGPRAAPEVYAFATFEWPGSRDKRTLACLIQNFMPEDISVQWLHNEVQLPDARHSTTQPR KTKGSGFFVFSRLEVTRAEWEQKDEFICRAVHEAASPSQTVQRAVSVNPESSRRGGC |
|||||
| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS057 | [1] | ||||
| Scaffold Name | scFv | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Fibronectin | Inhibitor | Brain cancer [ICD-11: 2A00.5]; Haematological malignancies [ICD-11: 2B33.Y]; Hodgkin lymphoma [ICD-11: 2B30.Z]; Non-small cell lung cancer [ICD-11: 2C25.Y]; Solid tumour/cancer [ICD-11: 2A00-2F9Z] | N.A. | Philogen | [1] | |