General Information of Synthetic Binding Protein (SBP) (ID: SBP003287)
SBP Name
scFv anti-TO1-2p HL1-TO1
Synonyms
scFv HL1-TO1
Molecular Weight 26.1 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Yeast
Selection Method Yeast display
Highest Status Research
Sequence Length 397
SBP Sequence
>scFv anti-TO1-2p HL1-TO1
FSIKMQLLRCFSIFSVIASVLAQELTTICEQIPSPTLESTPYSLSTTTILANGKAMQGVF
EYYKSVTFVSNCGSHPSTTSKGSPINTQYVFKDNSSTIEGRYPYDVPDYALQASGGGGSG
GGGSGGGGSASQVQLVESEAEVKKPGSSVKVSCKASGGTFSSYAISWVRQAPGQGLEWMG
GIIPIFGTANYAQKFQGRVTITADESTSTAYMELSSLRSEDTAVYYCVLLDTTMVTGYYF
DYWGQGTLVTVSSGILGSGGGGSGGGGSGGGGSNFMLTQPPSASGTPGQSVTISCSGSGS
NIGNNKVNWYQQLPGTAPKLLIYSNNQRPSGVPDRFSGSKSGTSASLAISGLQSEDEADY
YCAAWDDSLNGYVFGTGTKLTVLSGILEQKLISEEDL
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
TO1-2p
BTS Info
Binder Research tool Kd: 360 nM Carnegie Mellon University [1]
References
1 Fluorogen-activating single-chain antibodies for imaging cell surface proteins. Nat Biotechnol. 2008 Feb;26(2):235-40.