General Information of Synthetic Binding Protein (SBP) (ID: SBP003241)
SBP Name
scFv anti-GA-pyridine AGE78
Synonyms
scFv AGE78
Molecular Weight 26.1 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 242
SBP Sequence
>scFv anti-GA-pyridine AGE78
QVKLQESGPSLVKPSQTLSLTCSVTGDSITSGYWNWIRKFPGNKFEYLGYISYSGRTYYN
PSLKSRISITRDTSKNQYYLHLNSVTTEDTATYYCTRPYHRYDFAIDYWGQGTTVTVSSG
GGGSGGGGSGGGGSDIELTQSPAIMSASPGEKVTMTCSASSSVSSSYMHWYQQKPGFSPK
LLIYRTSNLASGVPARFSGSGSGTSYSLTIGTMEAEDVATYYCQQGSSIPYTFGGGTKLE
IK
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
3-hydroxy-4-hydroxymethyl-1-(5-amino-5-carboxypentyl) pyridinium cation
BTS Info
Binder Research tool N.A. Kumamoto University [1]
References
1 Production of Single-Chain Fv Antibodies Specific for GA-Pyridine, an Advanced Glycation End-Product (AGE), with Reduced Inter-Domain Motion. Molecules. 2017 Oct 10;22(10):1695.