General Information of Synthetic Binding Protein (SBP) (ID: SBP003191)
SBP Name
Nanobody anti-GSN clone 11
Synonyms
Nb11
Molecular Weight 13.7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Southern screening
Highest Status Research
PDB ID 4S10; 4S11
Sequence Length 127
SBP Sequence
>Nanobody anti-GSN clone 11
QVQLQESGGGLVQAGGSLRLSCAASGRTFSSFVMGWFRQAPGKEREFVASISRSGSVTRY
ADSAKGRFTISKDNAKNTVSLQMDNLNPDDTAVYYCAADLHRPYGPGSQRTDDYDTWGQG
TQVTVSS
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Gelsolin
BTS Info
Binder Hereditary gelsolin amyloidosis N.A. Faculty of Medicine and Health Sciences [1]
References
1 An ER-directed gelsolin nanobody targets the first step in amyloid formation in a gelsolin amyloidosis mouse model. Hum Mol Genet. 2015 May 1;24(9):2492-507.