Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003138) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Monobody anti-KRas 12VC1
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| Synonyms |
Monobody 12VC1
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| Molecular Weight | 10.2 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Yeast | |||||
| Selection Method | Yeast display | |||||
| Highest Status | Research | |||||
| PDB ID | 7L0G | |||||
| Sequence Length | 97 | |||||
| SBP Sequence |
>Monobody anti-KRas 12VC1
GSVSSVPTKLEVVAATPTSLLISWDAPAVTVFFYVITYGETGHGVGAFQAFKVPGSKSTA TISGLKPGVDYTITVYARGYSKQGPYKPSPISINYRT |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS047 | [1] | ||||
| Scaffold Name | Monobody | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| GTPase KRas | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 9600 nM | New York University Langone Health | [1] | |
| GTPase KRas | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 100 nM | New York University Langone Health | [1] | |
| GTPase KRas | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 24.7 nM | New York University Langone Health | [1] | |