General Information of Synthetic Binding Protein (SBP) (ID: SBP003105)
SBP Name
scFv anti-CHL1 6C2
Synonyms
scFv 6C2
Molecular Weight 24.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli TG1
Selection Method Phage display
Highest Status Research
Sequence Length 237
SBP Sequence
>scFv anti-CHL1 6C2
EVQLVESGGGVVRPGGSLRLSCAASGFTFDDYGMSWVRQAPGKGPEWVSGINWNGGSTGY
ADSVKGRFTISRDNAKNSLYLQMNSLRAEDTAVYYCARGKHSSRPWGQGTLVTVSRGGGS
GGGSGGGSSSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYGKNN
RPSGIPDRFSGSSSGNTASLTITGAQAEDEADYYCNSIAASTSSVVFGGGTKLTVLG
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Neural cell adhesion molecule L1-like protein
BTS Info
Binder Tools for promoting neurite outgrowth of hippocampal and cerebellar neurons in vitro Kd: 22.8 nM University of Hamburg [1]
References
1 Single-chain variable fragment antibodies against the neural adhesion molecule CHL1 (close homolog of L1) enhance neurite outgrowth. J Neurosci Res. 2002 Aug 15;69(4):437-47.