General Information of Synthetic Binding Protein (SBP) (ID: SBP001873)
SBP Name
BiTE anti-CD3/SV2B
Synonyms
21-3BiTE
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS018
Scaffold Info
[1]
Scaffold Name BiTE
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
T-cell surface glycoprotein CD3
BTS Info
Binder Cancers [ICD-11: 2D4Z] N.A. University of Toyama [1]
Survivin-2B-derived nonamer peptide SV2B80-88
BTS Info
Binder Cancers [ICD-11: 2D4Z] N.A. University of Toyama [1]
References
1 High throughput development of TCR-mimic antibody that targets survivin-2B 80-88/HLA-A*A24 and its application in a bispecific T-cell engager. Sci Rep. 2019 Jul 8;9(1):9827.