Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001863)
SBP Name	BiTE anti-CD19/CD3 AMG103
Synonyms	BiTE AMG103
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS018 Scaffold Info					[1]
Scaffold Name	BiTE
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
T-cell surface glycoprotein CD3	BTS Info	Binder	Cancers [ICD-11: 2D4Z]	N.A.	Amgen; University of Liege	[1]
B-lymphocyte antigen CD19	BTS Info	Binder	Cancers [ICD-11: 2D4Z]	N.A.	Amgen; University of Liege	[1]

References

1

Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies. Front Immunol. 2020 May 7;11:762.