General Information of Synthetic Binding Protein (SBP) (ID: SBP001860)
SBP Name
BiTE anti-FAPalpha
Synonyms
FBiTE
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS018
Scaffold Info
[1]
Scaffold Name BiTE
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Prolyl endopeptidase FAP
BTS Info
Binder Tumors [ICD-11: XH1N44] N.A. Adibel Cancer Institute [1]
References
1 Targeting the tumor stroma with an oncolytic adenovirus secreting a fibroblast activation protein-targeted bispecific T-cell engager. J Immunother Cancer. 2019 Jan 25;7(1):19.