Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001814)
SBP Name	scFv anti-ERBB1 72000
Synonyms	scFv 72000
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli HB101
Highest Status	Research
Template Name	Matuzumab

Protein Scaffold Information of This SBP
Scaffold ID	PS057 Scaffold Info					[1] , [2]
Scaffold Name	scFv
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Epidermal growth factor receptor	BTS Info	Binder	EGFR-specific cancer	N.A.	Chemotherapeutisches Forschungsinstitut; University of Texas	[1] , [2]

References

1	Peptide mimotopes recognized by antibodies cetuximab and matuzumab induce a functionally equivalent anti-EGFR immune response. Oncogene. 2010 Aug 12;29(32):4517-27.
2	Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines. Nat Biotechnol. 1997 Jan;15(1):29-34.