General Information of Synthetic Binding Protein (SBP) (ID: SBP001791)
SBP Name
scFv anti-Fn7B8 L19
Synonyms
scFv L19
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Fibronectin
BTS Info
Binder Cancers [ICD-11: 2D4Z] Kd: 144 nM Technical University of Munich [1]
References
1 Combinatorial design of an Anticalin directed against the extra-domain b for the specific targeting of oncofetal fibronectin. J Mol Biol. 2013 Feb 22;425(4):780-802.