General Information of Synthetic Binding Protein (SBP) (ID: SBP001783)
SBP Name
scFv anti-TACE H7
Synonyms
scFv H7
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli BL21 (DE3)
Selection Method Phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Disintegrin and metalloproteinase domain-containing protein 17
BTS Info
Inhibitor Cancers [ICD-11: 2D4Z] Kd: 0.05 nM University of Cambridge [1]
References
1 Development of a 'mouse and human cross-reactive' affinity-matured exosite inhibitory human antibody specific to TACE (ADAM17) for cancer immunotherapy. Protein Eng Des Sel. 2014 Jun;27(6):179-90.