General Information of Synthetic Binding Protein (SBP) (ID: SBP001707)
SBP Name
scFv anti-HIV-1 clone m6
Synonyms
scFv m6
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli Top 10
Selection Method Phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Envelope glycoprotein gp160
BTS Info
Inhibitor Human immunodeficiency virus type 1 infection [ICD-11: XN8LD] N.A. National Cancer Institute-Frederick [1]
References
1 Improved breadth and potency of an HIV-1-neutralizing human single-chain antibody by random mutagenesis and sequential antigen panning. J Mol Biol. 2004 Jan 2;335(1):209-19.