Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001676)
SBP Name
scFv anti-CD22 HA22
Synonyms
scFv HA22
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Mammalian cells
Selection Method HEK 293T cell surface display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
B-cell receptor CD22
BTS Info
Binder CD22-expressing cancers Kd: 2.5 nM National Cancer Institute [1]
References
1 Isolation of anti-CD22 Fv with high affinity by Fv display on human cells. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9637-42.