Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001628) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv anti-CSPG4 UC4
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| Synonyms |
scFv UC4
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| Molecular Weight | 26.4 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Yeast display | |||||
| Highest Status | Research | |||||
| Sequence Length | 252 | |||||
| SBP Sequence |
>scFv anti-CSPG4 UC4
EVQLVESGAEVKKPGDSLKISCKGSGYSFTSYWIGWVRQMPGKGLEWMGIIYPGDSVTTY SPAFQGDVTISVDKSIGAAYLQWNISLKASDTGIYYCARRRGNYYMDVWGNGTLVTVSSL KSGGGGSGGGGPGGGGSRSTQSALTQPASVSGSPGQSITISCTGTSRDVGGYNYVSWYQQ HPGKAPKLMIYDVSNRPSGVSNRFSGSKSGNTASLTISGLQAEDEAVYYCSSYTSSSTRY VFGTGTQLTVLG |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | scFv 1H10 | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS057 | [1] | ||||
| Scaffold Name | scFv | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Chondroitin sulfate proteoglycan 4 | Binder | Cancers [ICD-11: 2D4Z] | Kd: 2.5 nM | Duke University | [1] | |