Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001615) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
scFv anti-IL-17A 8D3
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| Synonyms |
scFv 8D3
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| Thermal Denaturation TEMP | 59.4 ℃ | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Yeast display | |||||
| Highest Status | Research | |||||
| SBP Sequence |
>VH Chain
QVQLQQSGPGLVKPPQTLSLTCAISGDSVSSNSAAWDWIRQSPSRGLEWLGRTYYRSKWS HDYAVSVKNRITINPDTSKNQFSLQLNSVSPEDTAVYYCVREGDYGDYGYWGQGTLVTVS S >VL Chain SSELTQDPAVSVALGQTVRITCQGDSLRGYYASWYQQKPGQAPVLVIYYDDDRPTGIPER FSGSNSGNSATLTISRVEAGDEADYYCAAWDVSLNGPVFGGGTKVTVLS |
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| Template Name | scFv 7H9 | |||||
| Template Sequence |
>VH Chain
QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTYYRSKWS HDYAVSVKSRITINPDTSKNQFSLQLNSVTPEDTAVYYCAREGEYGDYGYWGQGTLVTVS S >VL Chain SSELTQDPAVSVALGQTVRITCQGDSLRSYYASWYQQKPGQAPVLVIYYDDDRPTGIPER FSGSNSGNTATLTISRVEAGDEADYYCAAWDDSLNGPVFGGGTKVTVLS |
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| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS057 | [1] | ||||
| Scaffold Name | scFv | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Interleukin-17A | Binder | Autoimmune disease [ICD-11: 4A4Z]; Cancers [ICD-11: 2D4Z] | Kd: 0.47 nM | Chinese Academy of Medical Sciences & Peking Union Medical College | [1] | |