Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP001563) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Fab anti-GAD65 b96.11
|
|||||
| Synonyms |
Fab b96.11
|
|||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| SBP Sequence |
>Heavy Chain
EVQLVESGGGLVQPGRSLRLSCSASGFTFGDYAMSWFRLAPGKGLEWVGIIKSRAIDGTP QYAASVKGRFTISRDDSNSIAYLQMNSLTTEDTAIYYCARDFYDFWNEFSHRTFDFWGQG TLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTF PAVLQSSGLYSLSSVVTVPSPSSSLGTQTYICNVNHKPSNTKVDKRVEPK >Light Chain QSALTQPASASGSPGQSVTITCTGSSSDVGGYKYVSWYQHHPGKAPKLMIYEVSKRPSGV PDRFSGSKSGNMASLTVSGLQAEDEADYYCSSYAGSYNFYVFGNGTKVTVLGQPKANPTV TLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVNAGVETTKPSKQSNNKYAAS SYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
|||||
| Template Name | Fab B7-15A2 | |||||
| Template Sequence |
>Heavy Chain
QVQLVESGGGVVQPGRSLRLSCAASGFTFNNYAIHWVRQAPGKGLEWVAFISYDGSKNYY ADSVKGRFTISRDNSKNTLFLQMNSLRPEDTAIYYCARVLFQQLVLYAPFDIWGQGTMVT VSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVL QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC >Light Chain QNVLTQPPSVSGAPGQRVTISCTGSNSNIGAGFTVHWYQHLPGTAPKLLIFANTNRPSGV PDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSARFGGGTRLTVLGQPKAAPSVT LFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVNAGVETTKPSKQSNNKYAASS YLSLTPEQWKSHKSYSCQVTHEGSTVEKTVAPAECS |
|||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS034 | [1] | ||||
| Scaffold Name | Fab | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Glutamate decarboxylase 2 | Inhibitor | Type 1 diabetes mellitus [ICD-11: 5A10] | N.A. | Monash University | [1] | |